Tag Archives: STR analysis

NGS Moving Towards Forensics

To me the article “Early Adopters Say NGS-based Forensic Testing Could Lead to More Precise Identification” by GenomeWeb (http://bit.ly/WKKIPC) is a very good sign of the “maturation” of the rather young next generation technology. It may find its way into criminal police offices soon.

Currently, forensic profiling is based on STR analysis with capillary electrophoresis, or analysis of mitochondrial DNA with PCR and Sanger sequencing. But next gen sequencing opens up new possibilities. Researchers are now looking at moving both STR profiling and mitochondrial DNA analysis to next gen sequencing, but are also looking to develop SNP-based targeted sequencing panels for forensics, which would enable researchers to identify a person’s ancestry, hair color, or other defining characteristics based on their DNA.

So, what do you think: Will there still be classical DNA profiling or will NGS have taken over in the next decade?