Recently, a number of groups have attempted to compare the two platforms PGM and MiSeq, including the Sanger Institute a group from the University of Birmingham, and BGI. None of these studies have conclusively named a winner, and each group comes to slightly different conclusions.
In a blog of Genome Web’s “The Daily Scan” the different findings in the three comparison studies are discussed heavily. On the one hand different chemistries or older versions are compared with newer ones, on the other hand different application require different technologies.
According to a report by Jon Groberg at Macquarie Equities Research, Groberg cites several factors leading to Life Tech’s better selling success of the PGM over Illumina’s MiSeq (1300 vs. 700 systems sold): price — the PGM sells for $75,000, while the MiSeq goes for $125,000; Life has a more extensive commercial reach; the trajectory of improvement for the PGM is greater than for the MiSeq; and the PGM excels at certain key applications.
Of note are the differences in sequencing cost, based on list prices (see Sanger Institute study). The MiSeq came out cheapest, at $502 per gigabase, followed by the PGM, at $1,000 per gigabase using the Ion 318 chip, and the PacBio, at $2,000 per gigabase. All three platforms produce data at a greater cost than the Illumina GAIIx, at $148 per gigabase, and the HiSeq 2000, at $41 per gigabase.
What is your experience with the two systems?