Tag Archives: cancer

Large genome sequencing studies in the USA

senior-asian-woman-100226669The launch of the Illumina HiSeq X Ten enabled them to put in practice their plans and great visions. I’m speaking of two persons of great influence in the United States. This year, Dr. J. Craig Venter, known for being one of the first to sequence the human genome and Patrick Soon-Shiong, considered as the world’s richest doctor, both revealed some details about their large scale sequencing projects:

  • J. Craig Venter founded the company Human Longevity that aims to develop treatments for cancer and age-related conditions. To unveil the mechanisms how people can live long and healthy lifes, the company will become one of the largest DNA sequencing facilities in the world. The plan is to set up a sequencing center that is capable of sequencing 40,000 human genomes a year.
  • Patrick Soon-Shiong recently announced that his company NantHealth is purchasing sequencers being able to sequence 22,000 genomes annually. The samples will derive from the 22,000 patients diagnosed with cancer annually at the 34 hospitals owned by Providence Health & Services. Consequently, the company from Soon-Shiong probably will become the first one using their sequencing capacity for clinical sequencing on a large scale.

Such huge collections of sequencing data make it possible to uncover the molecular causes of an complex process as aging or such a diverse and complex disease as cancer in a general approach. Big and very valuable databases will be created, that may contribute to develop new pharmaceuticals or develop personalized therapies.

Tumor Heterogeneity And The Underlying Genetics

Although this recorded seminar is promoted by Illumina, I still can recommend it as a very good talk about basic concepts on tumor heterogeneity and the underlying genetics. Kenneth Bloom, Chief Medical Officer at Clarient (GE Healthcare) and a pathologist, explains the needs for the application of NGS in clinical lab in a simple and very vivid manner. While watching this video I gained a better idea of the needs of a diagnostics lab and the challenges in developing a diagnostic NGS panel.

GENReport: NGS Trends In Cancer Research & Clinics

GENReport_Publication growth
Enal Razvi, Ph.D. from SelectBio U.S. summarised very nicely the trends of next generation sequencing in cancer research and cancer diagnostics for Genetic Engineering & Biotechnology News.

Visit the GEN website to download the complete PDF report.

Genetics of Cancer

While I was browsing the internet for news on NGS and cancer sequencing, I came across the YouTube link below.  The famous oncologist Bert Vogelstein gave this amazing talk about genetics of cancer over a year ago. To my opinion he outlines very nicely the concepts of oncological marker discovery and how we could/should make use of the next generation sequencing technology. Although it’s a long talk, it is worth while watching at least the first part of the talk.